The purpose of this Roundtable is to improve the organization and delivery of care with the goal of optimizing health, functional status, and well-being as the US population ages. This invitation-only, interactive roundtable discussion will convene approximately twenty-five experts within the field to identify levers where AHRQ can have the biggest impact with respect to both research and dissemination and implementation to foster healthy aging and prevention and management of multiple chronic conditions with a focus on primary care and ambulatory settings. Making progress towards this goal will require transforming our health system from one that focuses on disease and illness to one that is person-centered and provides care in the context of people’s lives aligned with their goals and preferences.